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Acne----HPA axis----and CRH RESEARCH pROOF

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Acne----HPA axis----and CRH

Posted by anonymous on May 15, 2002 at 00:06:56:

Dr. Stoll,
Looks like what you have been saying about acne, may have been excatly correct.
:)

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This is the actual abstract taken from the PNAS.
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Physiology
Corticotropin-releasing hormone: An autocrine hormone that promotes lipogenesis in human sebocytes
Christos C. Zouboulis*,, Holger Seltmann*, Naoki Hiroi,§, WenChieh Chen¶, Maggie Young§, Marina Oeff*, Werner A. Scherbaum, Constantin E. Orfanos*, Samuel M. McCann, and Stefan R. Bornstein,§
* Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, 14195 Berlin, Germany; Department of Endocrinology, University Medical Center, Heinrich Heine University of Duesseldorf, 40225 Duesseldorf, Germany; § Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Development, National Institutes of Health, Bethesda, MD 20892-1583; ¶ Department of Dermatology, College of Medicine, National Cheng Kung University, 704 Tainan, Taiwan; and Pennington Biomedical Research Center, Baton Rouge, LA 70808-4124

Contributed by Samuel M. McCann, March 27, 2002

Sebaceous glands may be involved in a pathway conceptually similar to that of the hypothalamic-pituitary-adrenal (HPA) axis. Such a pathway has been described and may occur in human skin and lately in the sebaceous glands because they express neuropeptide receptors. Corticotropin-releasing hormone (CRH) is the most proximal element of the HPA axis, and it acts as central coordinator for neuroendocrine and behavioral responses to stress. To further examine the probability of an HPA equivalent pathway, we investigated the expression of CRH, CRH-binding protein (CRH-BP), and CRH receptors (CRH-R) in SZ95 sebocytes in vitro and their regulation by CRH and several other hormones. CRH, CRH-BP, CRH-R1, and CRH-R2 were detectable in SZ95 sebocytes at the mRNA and protein levels: CRH-R1 was the predominant type (CRH-R1/CRH-R2 = 2). CRH was biologically active on human sebocytes: it induced biphasic increase in synthesis of sebaceous lipids with a maximum stimulation at 107 M and up-regulated mRNA levels of 3- hydroxysteroid dehydrogenase/5-4 isomerase, although it did not affect cell viability, cell proliferation, or IL-1-induced IL-8 release. CRH, dehydroepiandrosterone, and 17-estradiol did not modulate CRH-R expression, whereas testosterone at 107 M down-regulated CRH-R1 and CRH-R2 mRNA expression at 6 to 24 h, and growth hormone (GH) switched CRH-R1 mRNA expression to CRH-R2 at 24 h. Based on these findings, CRH may be an autocrine hormone for human sebocytes that exerts homeostatic lipogenic activity, whereas testosterone and growth hormone induce CRH negative feedback. The findings implicate CRH in the clinical development of acne, seborrhea, androgenetic alopecia, skin aging, xerosis, and other skin disorders associated with alterations in lipid formation of sebaceous origin.
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It's getting closer to scientific proof .....



Re: Acne----HPA axis----and CRH

Posted by Sandra on May 15, 2002 at 00:10:06:

In Reply to: Acne----HPA axis----and CRH posted by anonymous on May 15, 2002 at 00:06:56:

Thanks, but can someone now translate that for me.....



Re: Acne----HPA axis----and CRH

Posted by anonymous on May 15, 2002 at 01:44:26:

In Reply to: Re: Acne----HPA axis----and CRH posted by Sandra on May 15, 2002 at 00:10:06:

:)
That's what Doc Stoll is for ....
;)


Hey Doc check out what this traditional dermatologist has to say when I talk about SR. He says he's in his 2nd year residency. Typical

http://pub106.ezboard.com/fabsoluteacneinfofrm1.showMessageRange?topicID=515.topic&start=101&stop=120

You'll prob. get a kick out of it.
lol



Re: Acne----HPA axis----and CRH

Posted by anonymous on May 15, 2002 at 01:46:43:

In Reply to: Re: Acne----HPA axis----and CRH posted by anonymous on May 15, 2002 at 01:44:26:

It's about half way down, docs name is Dragon.
No need to reply about it, just thought you'd get a kick
;)

Follow Ups:


Re: Acne----HPA axis----and CRH

Posted by anonymous on May 15, 2002 at 05:37:45:

In Reply to: Re: Acne----HPA axis----and CRH posted by anonymous on May 15, 2002 at 01:44:26:

Juicy stuff is on the last few pages..
;)

Follow Ups:


Re: Acne----HPA axis----and CRH (Archive.) RESEARCH

Posted by Walt Stoll on May 16, 2002 at 07:56:15:

In Reply to: Acne----HPA axis----and CRH posted by anonymous on May 15, 2002 at 00:06:56:

Thanks, anonymous.

Eventually, the truth tends to come out.

Namaste`

Walt



CNN acne report Url Link

Posted by Now it had hit the mass media on May 16, 2002 at 08:00:16:

In Reply to: Re: Acne----HPA axis----and CRH (Archive.) RESEARCH posted by Walt Stoll on May 16, 2002 at 07:56:15:


feadfg



Re: CNN acne report Url Link

Posted by OK - link pasted on May 16, 2002 at 08:02:06:

In Reply to: CNN acne report Url Link posted by Now it had hit the mass media on May 16, 2002 at 08:00:16:


http://www.cnn.com/2002/HEALTH/conditions/05/14/acne.stress/index.html

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