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GAD Inhibitor for type 1 diabetes question

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GAD Inhibitor for type 1 diabetes question

Posted by Mike-S on September 03, 1999 at 01:13:13:

Dr. Stoll: I have questions on the following article regarding a relationship between type 1 diabetes and GAD (url for reference only: http://www.chicagotribune.com/familyhealth/health/article/0,2669,ART-33743,FF.html
"The formation of GABA occurs by the decarboxylation of glutamate catalyzed by glutamate decarboxylase (GAD). GAD is present in many nerve endings of the brain as well as in the b-cells of the pancreas." Quoted from: http://web.indstate.edu/thcme/mwking/nerves.html by clicking on GABA.

Do any herbs, supplements, foods, etc. act as a GAD inhibitor and if so what are the dangers of this inhibition?
Does this glutamate have any relationship to monosodium-glutamate?
Is it possible for GAD to negatively affect the brain causing various brain disorders or diseases? (especially Alzheimer's?)
Link below is the article on type 1 diabetes. Links are included as reference only.
Thank you in advance for any help! Mike.



Re: GAD Inhibitor for type 1 diabetes question (Archive under diabetes--both this note and Mike's note.)

Posted by Walt Stoll on September 04, 1999 at 09:26:19:

In Reply to: GAD Inhibitor for type 1 diabetes question posted by Mike-S on September 03, 1999 at 01:13:13:

Thanks, Mike.

I was not aware of this intermediate step in the causal chain that begins with the ingestion of cows' milk in infants. Interesting that they carefully made no mention of this fact in their entire article.

So far as I can tell, this is a good example of the lengths the conventional system will go to promote an expensive solution to a simple problem that could be resolved by education alone. You can bet that they will be scrambling to develop a drug that can help prevent the formation of this substance while ignoring the fact that all people would have to do is not give their infants cows' milk.

I have no idea of what herbs or supplements might help. I have been trying (for years) to get people to learn about the risks of cows' milk in their infants to prevent this problem. I still think that that is the answer and not to continue the cause while trying to block the effect.

Walt



Re: GAD Inhibitor for type 1 diabetes question (Archive under diabetes--both this note and Mike's note.)

Posted by Mike-S on September 06, 1999 at 00:09:37:

In Reply to: Re: GAD Inhibitor for type 1 diabetes question (Archive under diabetes--both this note and Mike's note.) posted by Walt Stoll on September 04, 1999 at 09:26:19:


Dr. Stoll: I received this link with a little more information on glutamate. Are you aware of any GAD protein inhibitor (drug or otherwise) that is currently in existence. GAD is not on the database where I look these things up so I cannot find a substitute for a drug (if any currently exist). Thank you very much! If I find any info I'll post it. Mike



Re: GAD Inhibitor for type 1 diabetes question - L-malate?

Posted by Mike-S on September 06, 1999 at 03:37:56:

In Reply to: Re: GAD Inhibitor for type 1 diabetes question (Archive under diabetes--both this note and Mike's note.) posted by Walt Stoll on September 04, 1999 at 09:26:19:


Dr. Stoll: I received a response that I believe says L-malate will inhibit the GAD protein for type 1 diabetes: http://x34.deja.com/getdoc.xp?AN=521263942&CONTEXT=936600763.1054081134&hitnum=1 This site contains L-malate info:
http://www-personal.ksu.edu/~wfu/bioch755/glycogen.htm (a search / find on 'figure' shows something about a citric acid cycle; it also shows that all of this is way beyond my knowledge of any of this). Does all this mean citric acid -or- L-malate (what is L-malate?) will help with type 1 diabetes? Thank you very much. Mike-S



Re: GAD Inhibitor for type 1 diabetes question (Archive under diabetes--both this note and Mike's note.)

Posted by Walt Stoll on September 07, 1999 at 10:02:13:

In Reply to: Re: GAD Inhibitor for type 1 diabetes question (Archive under diabetes--both this note and Mike's note.) posted by Mike-S on September 06, 1999 at 00:09:37:

No, Mike, I do not.

However, I might have some leads as to where you might find someone who would. Try the website at healthcomm.com and call (800) 692-9400 and ask the tech. support there.

Walt



Re: GAD Inhibitor for type 1 diabetes question - L-malate?

Posted by Walt Stoll on September 07, 1999 at 10:21:44:

In Reply to: Re: GAD Inhibitor for type 1 diabetes question - L-malate? posted by Mike-S on September 06, 1999 at 03:37:56:

Thanks, Mike.

The best place I know of to answer questions like this is the website I recokmmended to you at healthcomm.com

Let us know what you learn and I can learn along with everyone else.

Walt



Re: GAD Inhibitor for type 1 diabetes question - L-malate is malic acid and best alleged source is apples- nmi

Posted by Mike-S on September 08, 1999 at 10:38:09:

In Reply to: Re: GAD Inhibitor for type 1 diabetes question - L-malate? posted by Walt Stoll on September 07, 1999 at 10:21:44:


nmi



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